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Parkinson's disease (PD) is a neurodegenerative neurological disease characterized by a decrease in dopaminergic neurons in the substantia nigra pars compacta (SNpc) and lowered dopamine concentrations in the basal ganglia. Therefore, further studies with better designs will be needed. However, due to the small number of randomized controlled trials and methodological limitations, we are unable to draw concrete conclusions. Exercise therapies might promote improvements in the motor symptoms of Parkinson's disease. Exercise therapies were found to be relatively safe. In comparison to patients who performed regular activity, patients who underwent exercise therapies exhibited statistically significant improvements in the total UPDRS, UPDRS II, and UPDRS III. Patients who underwent exercise therapies exhibited statistically significant improvements in the total UPDRS, UPDRS II and III, Berg Balance Scale, preferred walking speed, and Timed Up and Go Test compared to patients who underwent nonexercise therapies. The overall methodological quality was not high. Eighteen studies (1,144 patients) were included. Randomized controlled trials that evaluated exercise therapies in patients with Parkinson's disease until December 2016 were searched for in five electronic databases: PubMed, CENTRAL, EMBASE, OASIS, and CNKI. The present study aimed to evaluate efficacy and safety of exercise therapies for Parkinson's disease.
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Recently, rehabilitative exercise therapies have been described as an important method of overcoming the limitations of the conventional therapies for Parkinson's disease.